10 Best Heartworm Medicines for Dogs in 2024: Top Products Reviewed

As a responsible pet owner, ensuring your dog’s health and well-being is paramount. One of the most critical aspects of canine health is protecting your furry friend from heartworms. Heartworm disease is a serious and potentially fatal illness caused by parasitic worms transmitted through mosquito bites. Thankfully, there are effective heartworm preventatives available, and we’ve compiled a list of the best heartworm medicine for dogs available on Amazon in 2024. This guide not only reviews each product but also provides insight into what to look for when choosing heartworm medicine.

# Preview Product Rating Price
1 PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs &... No ratings yet $16.98
2 DURVET 12-Pack Triple Wormer Tablets for Puppies and Small Dogs DURVET 12-Pack Triple Wormer Tablets for Puppies and Small Dogs No ratings yet $30.99
3 Durvet Triple Wormer for Medium and Large Dogs Durvet Triple Wormer for Medium and Large Dogs No ratings yet $52.78
4 SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Medium and Large Dogs over 25 lbs, 2 Count SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Medium and Large Dogs... No ratings yet $22.33
5 Wormx Plus DeWormer, Large Dog, 6-Ct. Wormx Plus DeWormer, Large Dog, 6-Ct. No ratings yet $32.04
6 Elanco Chewable Quad Dewormer for Small Dogs, 2-25 lbs, 4 Chewable Tablets, White Elanco Chewable Quad Dewormer for Small Dogs, 2-25 lbs, 4 Chewable Tablets, White No ratings yet $23.98
7 Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6 Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6 No ratings yet $74.68
8 SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Puppies and Small Dogs, 6-25 lbs, Chewable, 2 Count SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Puppies and Small Dogs,... No ratings yet $15.99
9 K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55... No ratings yet $31.69
10 Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops |... No ratings yet $26.97

Why Heartworm Prevention is Important

Heartworms can grow up to a foot long and live within a dog’s heart and lungs, leading to severe health complications. Recognizing the importance of preventive care is essential to ensure your pet remains healthy and happy. Heartworm medicine can effectively prevent infection, making it a must-have in every dog owner’s arsenal.

Buying Guide for Heartworm Medicine for Dogs

When selecting heartworm medicine for your dog, consider the following factors:

  1. Age and Weight: Different products cater to varying weight categories and age groups, so ensure you choose one that fits your dog’s profile.

  2. Type of Medication: Medications can vary from oral tablets to topical treatments and injections. Choose what’s most manageable for you and your dog.

  3. Monthly vs. Annual Administration: Some medications require monthly doses while others might provide longer-lasting effects. Consider your convenience and your dog’s needs.

  4. Vet Recommendation: Always consult your veterinarian before starting any heartworm medication to get guidance tailored to your pet’s specific health requirements.

  5. Active Ingredients: Research the ingredients to understand how they work and any potential side effects.

  6. User Reviews: Check customer feedback to glean insights from other pet owners about effectiveness and potential issues.

With this guide in mind, let’s take a closer look at the top 10 heartworm medicines available on Amazon.

Top 10 Heartworm Medicines for Dogs

1. Heartgard Plus Chewables

Heartgard Plus Chewables are a popular choice among dog owners. These monthly chewable tablets are designed to prevent heartworm disease while treating and controlling roundworms and hookworms. They are beef-flavored, making them highly palatable for dogs.

The active ingredients, Ivermectin and Pyrantel, work synergistically to eliminate common intestinal parasites. Heartgard Plus is suitable for dogs of all ages, and its effectiveness has made it a veterinarian favorite.

OFF -$5.62Bestseller No. 1
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)
PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Large Dogs Dogs (45-88 lbs)
  • Effective, Waterproof Flea Treatment for Dogs: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application
  • Trusted, Vet Quality* Formula: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas within 24 hours
  • Break the Flea Cycle: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle! Kill flea eggs and larvae to prevent re-infestation
  • Fast Acting Long-Lasting Flea and Tick Protection: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts 6 months
  • Easy-to-use, Long-Lasting: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for six (6) months, or one year

2. Interceptor Plus

Interceptor Plus is a chewable tablet that protects against heartworms and also treats common intestinal worms. It has a beef flavor that dogs love, ensuring ease of administration. The active ingredients—Milbemycin oxime and Praziquantel—offer broad-spectrum protection.

This product is ideal for dogs of all sizes and can be used in puppies as young as 6 weeks. Interceptor Plus is well-regarded for its efficacy and safety.

Bestseller No. 1
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables
  • Dewormer for Dogs: PetArmor 7 Way Chewable De-Wormer for dogs treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms
  • Vet Quality: These vet-quality tablets are safe for puppies 12 weeks or older, and large dogs 25.1 to 200 lbs
  • Dewormer Tablets: PetArmor broad spectrum dewormer comes in chewable tablets, making it easy and convenient to give to your dog
  • How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dog dewomer is not rejected and the full dose of dewormer is eaten
  • Recommended Use: For best results with any PetArmor dog dewormer read and follow label intructions. If you need to retreat your dog, we recommend consulting with your veterinarian and have them perform a fecal test to rule out any other issues or parasites

3. Revolution for Dogs

Revolution is a topical solution that not only prevents heartworms but also protects against fleas, ticks, and certain types of mites. This monthly treatment is easy to apply and quickly absorbs into the skin.

The active ingredient, Selamectin, is effective for dogs over 6 weeks old. Revolution’s comprehensive protection makes it a preferred choice for dog owners who want an all-in-one solution.

OFF -$2.79Bestseller No. 1
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply
  • K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

4. Advantage Multi for Dogs

Advantage Multi is a topical solution that prevents heartworm disease while also controlling fleas, roundworms, hookworms, and whipworms. It features the active ingredient, Imidacloprid, coupled with Moxidectin, which is effective against heartworms.

This product is suitable for dogs over 7 weeks old, making it an effective preventive option. Dog owners appreciate its versatility in protecting against multiple infestations.

Bestseller No. 1
Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply
Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 6-Month Supply
  • Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours

5. ProHeart 12

ProHeart 12 is an injectable heartworm prevention given once a year. This product offers a long-lasting effect and is convenient for busy dog owners who may forget monthly administration.

The active ingredient is Moxidectin, providing effective protection against heartworms. ProHeart 12 is suitable for dogs 12 weeks and older, making it a fantastic option for those seeking long-term protection.

Bestseller No. 1
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Small Dogs & Puppies (6-25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables
PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Small Dogs & Puppies (6-25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables
  • Dewormer for Dogs: PetArmor 7 Way Chewable De-Wormer for dogs treats and controls 7 species of worms: 2 types of tapeworms, 2 types of roundworms, and 3 types of hookworms
  • Vet Quality: These vet-quality tablets are safe for puppies 12 weeks or older, and small dogs 6.0 to 25 lbs
  • Dewormer Tablets: PetArmor broad spectrum dewormer comes in chewable tablets, making it easy and convenient to give to your dog
  • How to Use: Watch your dog for a few minutes after dosing to make sure the chewable dog dewomer is not rejected and the full dose of dewormer is eaten
  • Recommended Use: For best results with any PetArmor dog dewormer read and follow label intructions. If you need to retreat your dog, we recommend consulting with your veterinarian and have them perform a fecal test to rule out any other issues or parasites

6. Sentinel Spectrum

Sentinel Spectrum is a monthly chewable that not only prevents heartworms but also treats and controls fleas and intestinal worms. It has tasty flavors and is formulated for dogs of different sizes.

The combination of Lufenuron, Milbemycin oxime, and Praziquantel provides comprehensive protection. This product is suitable for dogs from 2 pounds, making it a versatile choice for small breeds.

Bestseller No. 1
Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment
  • COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix II for Dogs. Includes 4 monthly doses
  • ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to bites and potential flea borne illnesses
  • STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea eggs and larvae within 12 hours of application
  • EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection for 30 days per application
  • MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect your dog with confidence

7. Comfortis

Comfortis is primarily known for its flea prevention and treatment but also has some formulations that assist in heartworm prevention. This oral tablet works quickly to eliminate fleas and is easy to administer due to its beef flavor.

While not a standalone heartworm preventative, it’s often used in conjunction with heartworm medications for comprehensive protection against parasites.

OFF -$2.01Bestseller No. 1
Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses
Capstar(nitenpyram) for Dogs Fast-Acting Oral Flea Treatment for Dogs 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses
  • Fast-Acting Flea Treatment: CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
  • Tackle Flea Infestations Fast: With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
  • Treat Reinfestations Fast: If your pet gets reinfested with fleas, simply give another dose as often as once a day
  • No Prescription Needed: Fast, effective flea treatment for dogs that's available over the counter
  • Intended Use: CAPSTAR Oral Flea Treatment for Small Dogs (57 mg) is safe for dogs and puppies 4 weeks and older that weigh 2-25 pounds

8. Trifexis

Trifexis is another oral chewable that combines flea prevention (Spinosad) with heartworm prevention (Milbemycin oxime) and also treats hookworms, roundworms, and whipworms.

This product is suitable for dogs over 8 weeks old and has a beef flavor that dogs love, making it a seamless addition to your dog’s routine.

OFF -$2.04Bestseller No. 1
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)
PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Dogs Over 25 lbs, 6 Doses (Pack of 1) (Packaging May Vary)
  • Powerful Ingredients: CAPACTION flea tablets contain the same active ingredients as CAPSTAR (nitenpyram).
  • Quick and Easy: This flea and tick pill kills fleas fast: begins working within 30 minutes.
  • Proven Results: CAPACTION achieves greater than 90% effectiveness against adult fleas on dogs within 4 hours.
  • Easy-to-Use: CAPACTION is provided in a convenient oral tablet. No prescription needed.
  • Intended Use: CAPACTION oral flea tablets are intended for use on dogs weighing 25.1 to 200 pounds

9. K9 Advantix II

K9 Advantix II is a topical solution that repels and kills fleas, ticks, and mosquitoes, preventing heartworm transmission. This powerful formula is fast-acting and lasts for up to 30 days.

While not primarily a heartworm preventative, its ability to repel mosquitoes can be a crucial part of comprehensive heartworm prevention. Suitable for dogs 7 weeks and older, K9 Advantix II is safe and effective.

OFF -$2.79Bestseller No. 1
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply
K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply
  • K9 Advantix II Large Dog 30-day treatment & prevention protects dogs 21-55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
  • Kills fleas within 12 hours of application
  • Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
  • Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
  • No prescription needed

10. Vet’s Best Heartworm Preventative

Vet’s Best offers a natural approach to heartworm prevention with a formulation of traditional ingredients that help keep mosquitoes at bay. This product can be used as an aid alongside other heartworm treatments.

While it may not be a standalone solution, it supports mosquito bite prevention, reducing the risk of heartworm transmission effectively.

OFF -$4.67Bestseller No. 1
Vet's Best Flea and Tick Spot-on Drops, Topical Flea and Tick Prevention for Dogs - Plant-Based Formula - Certified Natural Oils - for Large Dogs - 4 Month Supply
Vet's Best Flea and Tick Spot-on Drops, Topical Flea and Tick Prevention for Dogs - Plant-Based Formula - Certified Natural Oils - for Large Dogs - 4 Month Supply
  • LARGE DOG FLEA TREATMENT: Specifically designed for small dogs up to 15 pounds, our flea medicine for dogs applies directly to the skin, effectively killing and repelling fleas and ticks for a full month
  • CERTIFIED NATURAL: Give your dog the best with our blend of certified natural ingredients like clove, thyme, and cinnamon oil; our carefully selected ingredients make this natural tick repellent for dogs a safe and effective alternative to harsh chemicals
  • EASY APPLICATION: This flea repellent for dogs comes with an applicator that makes application a breeze; simply squeeze the desired amount onto your dog and let the formula do its work; say goodbye to messy flea medicine for dogs and hello to hassle-free tick and flea prevention for dogs
  • VETERINARIAN FORMULATED: Our flea and tick treatment for dogs is the result of years of research and testing by our top vets; we've combined the latest scientific advancements with natural ingredients to create a formula that is safe and highly effective
  • MADE IN THE USA: Our flea medicine for dogs is made in the USA with high-quality domestic and internationally sourced ingredients, ensuring that you are providing the best care possible for you beloved furry friend

Conclusion

Choosing the best heartworm medicine for dogs is essential for maintaining their health and well-being. From chewable tablets to topical solutions, there are numerous options available on Amazon, catering to various needs and preferences. Always consult with your veterinarian to determine which product best fits your dog’s specific health requirements.

By prioritizing preventive care, you can keep your furry friend safe from heartworm disease, giving you peace of mind and a happy, healthy companion for years to come.

# Preview Product Rating Price
1 PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs & Puppies (Over 25 lbs), Worm Remover (Praziquantel & Pyrantel Pamoate), 2 Flavored Chewables PetArmor 7 Way De-Wormer for Dogs, Oral Treatment for Tapeworm, Roundworm & Hookworm in Large Dogs &... No ratings yet $16.98
2 DURVET 12-Pack Triple Wormer Tablets for Puppies and Small Dogs DURVET 12-Pack Triple Wormer Tablets for Puppies and Small Dogs No ratings yet $30.99
3 Durvet Triple Wormer for Medium and Large Dogs Durvet Triple Wormer for Medium and Large Dogs No ratings yet $52.78
4 SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Medium and Large Dogs over 25 lbs, 2 Count SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Medium and Large Dogs... No ratings yet $22.33
5 Wormx Plus DeWormer, Large Dog, 6-Ct. Wormx Plus DeWormer, Large Dog, 6-Ct. No ratings yet $32.04
6 Elanco Chewable Quad Dewormer for Small Dogs, 2-25 lbs, 4 Chewable Tablets, White Elanco Chewable Quad Dewormer for Small Dogs, 2-25 lbs, 4 Chewable Tablets, White No ratings yet $23.98
7 Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6 Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6 No ratings yet $74.68
8 SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Puppies and Small Dogs, 6-25 lbs, Chewable, 2 Count SENTRY HC WORM X PLUS 7 Way De-Wormer (pyrantel pamoate/praziquantel), for Puppies and Small Dogs,... No ratings yet $15.99
9 K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55 lbs. | 2-Mo Supply K9 Advantix II Large Dog Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 21-55... No ratings yet $31.69
10 Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops | 4 Months Flea Treatment Activate II Flea and Tick Prevention for Dogs | 4 Count | Extra Large Dogs 55+ lbs | Topical Drops |... No ratings yet $26.97

Last update on 2024-09-20 / Affiliate links / Images from Amazon Product Advertising API | votechriscarrillo.com is a participant in the Amazon Associate program and will earn from qualifying purchases.

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